Inorganic Nanoparticles for Drug Delivery Systems: Design and Challenges
Article Sidebar
-
Drug Delivery, Inorganic Nanoparticles, Nanoparticle Design
Abstract
Inorganic nanoparticles have gained attention in drug delivery systems due to their unique properties, including high surface area, biocompatibility, and the ability to encapsulate therapeutic agents. These characteristics make them promising candidates for enhancing drug efficacy and targeting. This research aims to explore the design parameters and challenges associated with inorganic nanoparticles in drug delivery applications. The focus is on understanding how modifications in nanoparticle design can optimize performance and address existing limitations. A comprehensive literature review was conducted alongside experimental assessments of various inorganic nanoparticle formulations. Key parameters such as size, surface charge, and drug loading capacity were evaluated to assess their impact on drug delivery efficiency. In vitro studies were performed to analyze drug release profiles and cellular uptake.The findings indicate that specific design modifications significantly influence drug delivery performance. For example, smaller nanoparticles with positive surface charges exhibited enhanced cellular uptake and higher drug loading capacities. However, challenges such as stability, scalability, and regulatory hurdles remain prevalent in the field. Inorganic nanoparticles hold great potential for advancing drug delivery systems, but addressing associated design challenges is crucial. Continued research in this area will facilitate the development of more effective and safer drug delivery solutions, ultimately improving therapeutic outcomes for patients.
Full text article
References
Abuwatfa, W. H. (2022). Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems. Polymers, 14(5). https://doi.org/10.3390/polym14050925
Aydin, O., Janikas, Mark. V., Assunção, R. M., & Lee, T.-H. (2021). A quantitative comparison of regionalization methods. International Journal of Geographical Information Science, 35(11), 2287–2315. https://doi.org/10.1080/13658816.2021.1905819
Babu, P. J., Tirkey, A., & Rao, T. J. M. (2021). A review on recent technologies adopted by food industries and intervention of 2D-inorganic nanoparticles in food packaging applications. European Food Research and Technology, 247(12), 2899–2914. https://doi.org/10.1007/s00217-021-03848-1
Bharti, Jangwan, J. S., Kumar, G., Kumar, V., & Kumar, A. (2021). Abatement of organic and inorganic pollutants from drinking water by using commercial and laboratory-synthesized zinc oxide nanoparticles. SN Applied Sciences, 3(3), 311. https://doi.org/10.1007/s42452-021-04294-0
Bian, Y., Bai, M., Cao, J., & Li, J. (2023). A strong soybean meal adhesive enhanced by aluminum hydroxide nanoparticles via a low-cost and simple organic-inorganic hybrid strategy. International Journal of Adhesion and Adhesives, 125, 103442. https://doi.org/10.1016/j.ijadhadh.2023.103442
Bohannon, C. A., Chancellor, A. J., Kelly, M. T., Le, T. T., Zhu, L., Li, C. Y., & Zhao, B. (2021). Adaptable Multivalent Hairy Inorganic Nanoparticles. Journal of the American Chemical Society, 143(41), 16919–16924. https://doi.org/10.1021/jacs.1c08261
Bordbar-Khiabani, A. (2022). Smart Hydrogels for Advanced Drug Delivery Systems. International Journal of Molecular Sciences, 23(7). https://doi.org/10.3390/ijms23073665
Choradiya, B. R., & Patil, S. B. (2021). A comprehensive review on nanoemulsion as an ophthalmic drug delivery system. Journal of Molecular Liquids, 339, 116751. https://doi.org/10.1016/j.molliq.2021.116751
Faiz, F., Qiao, J., Lian, H., Mao, L., & Cui, X. (2022). A combination approach using two functionalized magnetic nanoparticles for speciation analysis of inorganic arsenic. Talanta, 237, 122939. https://doi.org/10.1016/j.talanta.2021.122939
Grassiri, B. (2021). Strategies to prolong the residence time of drug delivery systems on ocular surface. Advances in Colloid and Interface Science, 288(Query date: 2024-11-09 23:32:46). https://doi.org/10.1016/j.cis.2020.102342
Hodgson, E. L., Andersen, S. J., Troldborg, N., Forsting, A. M., Mikkelsen, R. F., & Sørensen, J. N. (2021). A Quantitative Comparison of Aeroelastic Computations using Flex5 and Actuator Methods in LES. Journal of Physics: Conference Series, 1934(1), 012014. https://doi.org/10.1088/1742-6596/1934/1/012014
Hu, H., Liu, Y., Lu, W. F., & Guo, X. (2022). A quantitative aesthetic measurement method for product appearance design. Advanced Engineering Informatics, 53, 101644. https://doi.org/10.1016/j.aei.2022.101644
Jing, X. (2022). The Intracellular and Extracellular Microenvironment of Tumor Site: The Trigger of Stimuli-Responsive Drug Delivery Systems. Small Methods, 6(3). https://doi.org/10.1002/smtd.202101437
Kaiser, P. (2021). Therapy of infected wounds: Overcoming clinical challenges by advanced drug delivery systems. Drug Delivery and Translational Research, 11(4), 1545–1567. https://doi.org/10.1007/s13346-021-00932-7
Kumar, V. (2021). Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis. Advanced Drug Delivery Reviews, 176(Query date: 2024-11-09 23:32:46). https://doi.org/10.1016/j.addr.2021.113888
Lemos, P. V. F. (2021). Starch chemical modifications applied to drug delivery systems: From fundamentals to FDA-approved raw materials. International Journal of Biological Macromolecules, 184(Query date: 2024-11-09 23:32:46), 218–234. https://doi.org/10.1016/j.ijbiomac.2021.06.077
Li, H. (2021). The protein corona and its effects on nanoparticle-based drug delivery systems. Acta Biomaterialia, 129(Query date: 2024-11-09 23:32:46), 57–72. https://doi.org/10.1016/j.actbio.2021.05.019
Liu, J., Tang, Q., Kou, J., Xu, D., Zhang, T., & Sun, S. (2022). A quantitative study on the approximation error and speed-up of the multi-scale MCMC (Monte Carlo Markov chain) method for molecular dynamics. Journal of Computational Physics, 469, 111491. https://doi.org/10.1016/j.jcp.2022.111491
Liu, P., Peng, J., Chen, Y., Liu, M., Tang, W., Guo, Z.-H., & Yue, K. (2021). A general and robust strategy for in-situ templated synthesis of patterned inorganic nanoparticle assemblies. Giant, 8, 100076. https://doi.org/10.1016/j.giant.2021.100076
Luiz, M. T. (2021). The use of TPGS in drug delivery systems to overcome biological barriers. European Polymer Journal, 142(Query date: 2024-11-09 23:32:46). https://doi.org/10.1016/j.eurpolymj.2020.110129
Luo, J., Li, H., & Wang, S. (2022). A quantitative reliability assessment and risk quantification method for microgrids considering supply and demand uncertainties. Applied Energy, 328, 120130. https://doi.org/10.1016/j.apenergy.2022.120130
Maji, I. (2021). Solid self emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos. Journal of Controlled Release, 337(Query date: 2024-11-09 23:32:46), 646–660. https://doi.org/10.1016/j.jconrel.2021.08.013
Mao, L. (2021). Targeted treatment for osteoarthritis: Drugs and delivery system. Drug Delivery, 28(1), 1861–1876. https://doi.org/10.1080/10717544.2021.1971798
Mazidi, Z. (2022). Smart stimuli-responsive implantable drug delivery systems for programmed and on-demand cancer treatment: An overview on the emerging materials. Chemical Engineering Journal, 433(Query date: 2024-11-09 23:32:46). https://doi.org/10.1016/j.cej.2022.134569
Munir, I. (2021). Therapeutic potential of graphyne as a new drug-delivery system for daunorubicin to treat cancer: A DFT study. Journal of Molecular Liquids, 336(Query date: 2024-11-09 23:32:46). https://doi.org/10.1016/j.molliq.2021.116327
Niu, W., Xiao, Q., Wang, X., Zhu, J., Li, J., Liang, X., Peng, Y., Wu, C., Lu, R., Pan, Y., Luo, J., Zhong, X., He, H., Rong, Z., Fan, J.-B., & Wang, Y. (2021). A Biomimetic Drug Delivery System by Integrating Grapefruit Extracellular Vesicles and Doxorubicin-Loaded Heparin-Based Nanoparticles for Glioma Therapy. Nano Letters, 21(3), 1484–1492. https://doi.org/10.1021/acs.nanolett.0c04753
Osman, N. (2022). Surface modification of nano-drug delivery systems for enhancing antibiotic delivery and activity. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 14(1). https://doi.org/10.1002/wnan.1758
Rahmanian-Devin, P. (2021). Thermosensitive Chitosan- ? -Glycerophosphate Hydrogels as Targeted Drug Delivery Systems: An Overview on Preparation and Their Applications. Advances in Pharmacological and Pharmaceutical Sciences, 2021(Query date: 2024-11-09 23:32:46). https://doi.org/10.1155/2021/6640893
Saha Chowdhury, S., Bera, B., & De, S. (2023). Adsorptive remediation of aqueous inorganic mercury with surfactant enhanced bismuth sulfide nanoparticles. Environmental Research, 219, 115145. https://doi.org/10.1016/j.envres.2022.115145
Satapathy, M. K. (2021). Solid lipid nanoparticles (Slns): An advanced drug delivery system targeting brain through bbb. Pharmaceutics, 13(8). https://doi.org/10.3390/pharmaceutics13081183
Sathishkumar, P. (2021). Zinc oxide-quercetin nanocomposite as a smart nano-drug delivery system: Molecular-level interaction studies. Applied Surface Science, 536(Query date: 2024-11-09 23:32:46). https://doi.org/10.1016/j.apsusc.2020.147741
Tian, B. (2021). Smart stimuli-responsive drug delivery systems based on cyclodextrin: A review. Carbohydrate Polymers, 251(Query date: 2024-11-09 23:32:46). https://doi.org/10.1016/j.carbpol.2020.116871
Wan, S., Cong, W., Shao, B., Wu, B., He, Q., Chen, Q., Shen, J., Chen, D., Hu, H.-G., Ye, F., Fan, C., Zhang, H., & Liu, K. (2021). A library of thermotropic liquid crystals of inorganic nanoparticles and extraordinary performances based on their collective ordering. Nano Today, 38, 101115. https://doi.org/10.1016/j.nantod.2021.101115
Wang, H. (2021). Update on Nanoparticle-Based Drug Delivery System for Anti-inflammatory Treatment. Frontiers in Bioengineering and Biotechnology, 9(Query date: 2024-11-09 23:32:46). https://doi.org/10.3389/fbioe.2021.630352
Wang, L., & Yan, Y. (2021). A Review of pH?Responsive Organic–Inorganic Hybrid Nanoparticles for RNAi?Based Therapeutics. Macromolecular Bioscience, 21(9), 2100183. https://doi.org/10.1002/mabi.202100183
Wang, X. (2022). Smart drug delivery systems for precise cancer therapy. Acta Pharmaceutica Sinica B, 12(11), 4098–4121. https://doi.org/10.1016/j.apsb.2022.08.013
Wei, P. (2021). Ultrasound-responsive polymer-based drug delivery systems. Drug Delivery and Translational Research, 11(4), 1323–1339. https://doi.org/10.1007/s13346-021-00963-0
Wu, Y., Xia, C., Cao, J., Al Garalleh, H., Garaleh, M., Khouj, M., & Pugazhendhi, A. (2023). A review on current scenario of Nanocatalysts in biofuel production and potential of organic and inorganic nanoparticles in biohydrogen production. Fuel, 338, 127216. https://doi.org/10.1016/j.fuel.2022.127216
Zhang, Y. (2021). Traditional Chinese medicine combined with pulmonary drug delivery system and idiopathic pulmonary fibrosis: Rationale and therapeutic potential. Biomedicine and Pharmacotherapy, 133(Query date: 2024-11-09 23:32:46). https://doi.org/10.1016/j.biopha.2020.111072
Zhu, J. (2022). Triggered azobenzene-based prodrugs and drug delivery systems. Journal of Controlled Release, 345(Query date: 2024-11-09 23:32:46), 475–493. https://doi.org/10.1016/j.jconrel.2022.03.041
Authors
Copyright (c) 2024 Dadang Muhammad Hasyim, Miku Fujita, Arnes Yuli Vandika
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
